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The US Summary Slides - HCT Trends and Survival Data

Using information from our outcomes database, CIBMTR annually prepares and distributes charts summarizing current uses and outcomes of allogeneic and autologous hematopoietic cell transplantation (HCT) in a set of US Summary Slides.

The US Summary Slides

The US Summary Slides are an annual report on data submitted to the CIBMTR by centers in the US and describes information related to practices and general survival outcomes after hematopoietic cell transplantation. The current edition includes transplants performed prior to 2020.

The US Summary Slides 2020 (PowerPoint)

(Select "Open in PowerPoint" option to view presentation)

  • Slides 2 to 37 exhibit data on frequency of transplants according to age, donor and transplant type, graft source, disease, conditioning regimen and causes of death. All frequencies represent first autologous and allogeneic transplants registered with the CIBMTR during the period. Slides 2, 3 and 4 represent estimated frequencies of total number of transplants in the US.
  • Slides 38 to 73 include overall survival outcomes according to disease, disease status, donor type, year of transplant and conditioning regimen intensity. Comparisons across survival curves are univariate and do not adjust for all potentially important factors; consequently, results should be interpreted cautiously. Slides demonstrating survival curves represent data from US only.

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To cite the US Summary Slides

Phelan, R., Arora, M., Chen, M. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR US summary slides, 2020.

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Request the US Summary Slides

Slides are also available upon request by contacting info-request@mcw.edu.

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Supplemental information on the US Summary Slides

  • Charts on slides 2, 3, 4 are estimates based on data reported to CIBMTR, adjusted according to transplant type. These adjustments come from comparisons with other national and international databases.

  • Acute myeloid leukemia (AML), and acute lymphocytic leukemia (ALL) have disease status at HCT classified as CR1, CR2 and relapse/ never in CR.

  • Myelodysplastic syndrome (MDS) is divided into:

    • Low risk (refractory anemia [RA] or refractory anemia with ringed sideroblasts [RARS], refractory cytopenia with unilineage dysplasia [RCUD], refractory cytopenia with multilineage dysplasia [RCMD], MDS with isolated del(5q)).

    • High risk (refractory anemia with excess blasts [RAEB] or chronic myelomonocytic leukemia [CMML]) disease).

  • Myeloproliferative neoplasms (MPNs) include myelofibrosis, polycythemia vera, essential thrombocythemia, chronic myelomonocytic leukemia, chronic myeloproliferative disease-unclassifiable, chronic neutrophilic leukemia, chronic eosinophilic leukemia and MPN-not otherwise specified.

  • Chronic myelogenous leukemia (CML) have disease stage classified as hematologic CR, chronic phase, accelerated phase or blast crisis

  • Lymphoma is classified according to sensitivity to prior chemotherapy (chemosensitive or chemoresistant).

  • The classification of conditioning regimen intensity is based on the agents, doses and schedules used. Several classification systems are available, and for this report we used a composite classification. Cases defined as reduced-intensity by the transplant center were classified as such. Cases without such information and with available data on chemotherapy agents, radiation and doses, were classified according to the CIBMTR operational definition of conditioning regimen intensity:

    • Myeloablative conditioning: regimens with total body irradiation doses of ≥500 cGY, single fractionated doses of ≥800 cGY, busulfan doses of >9mg/kg oral or Bu >= 7.2 mg/kg IV, or melphalan doses of >150 mg/m2 given as single agents or in combination with other drugs.

    • Reduced-intensity conditioning: regimens with lower doses of total body irradiation, fractionated radiation therapy, busulfan, and melphalan than those used to define a myeloablative conditioning regimen (above).

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Last Updated: 10/22/2021 8:59 AM
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