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Summary Slides - HCT Trends and Survival Data

Using information from our outcomes database, CIBMTR annually prepares and distributes charts summarizing current uses and outcomes of allogeneic and autologous hematopoietic cell transplantation (HCT) in a set of Summary Slides.

Summary Slides

The Summary Slides are an annual report on data submitted to the CIBMTR by centers worldwide and describes information related to practices and general survival outcomes after hematopoietic cell transplantation. The current edition includes transplants performed prior to 2014.

Summary Slides 2014 (PowerPoint)

  • Slides 3 to 15 exhibit data on frequency of transplants according to age, donor and transplant type, graft source and disease, and causes of death. All frequencies represent first autologous and allogeneic transplants registered with the CIBMTR during the period. Slides 3, 4, 5 and 9 represent estimated frequencies of total number of transplants in the US.
  • Slides 16 to 36 include overall survival outcomes according to disease, disease status, donor type, year of transplant and conditioning regimen intensity. Comparisons across survival curves are univariate and do not adjust for all potentially important factors; consequently, results should be interpreted cautiously.

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To cite Summary Slides

Pasquini MC, Zhu X. Current uses and outcomes of hematopoietic stem cell transplantation: 2014 CIBMTR Summary Slides. Available at: http://www.cibmtr.org

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Request Summary Slides

Slides are also available upon request by contacting inforequest@mcw.edu.

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Supplemental information on Summary Slides

 
  • Charts with total transplant numbers are estimates based on data reported to CIBMTR, adjusted according to transplant type. These adjustments come from comparisons with other national and international databases.
  • Acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML) are classified as:
    • early phase (first complete remission [CR1] or first chronic phase [CP1]),
    • intermediate phase (second or subsequent CR or CP or accelerated phase [AP]), or
    • advanced phase (primary induction failure, active disease or blastic phase) disease.
  • Myelodysplastic syndrome (MDS) is divided into:
    • early (refractory anemia [RA] or refractory anemia with ringed sideroblasts [RARS]), and
    • advanced (refractory anemia with excess blasts [RAEB] or chronic myelomonocytic leukemia [CMML]) disease.
  • Lymphoma is classified according to sensitivity to prior chemotherapy (chemosensitive or chemoresistant).
  • The classification of conditioning regimen intensities is based on the agents, doses and schedules used. Several classifications are available, and for this report we used a composite classification. Cases defined as reduced-intensity by the transplant center were classified as reported. Cases without such information and with available data on chemotherapy agents, radiation and doses, were classified according to the CIBMTR operational definition of conditioning regimen intensity:
    • Myeloablative conditioning regimen: regimens with total body irradiation single doses of ≥500 cGy, or fractionated doses totalling ≥800 cGy, busulfan doses of >9mg/kg, or melphalan doses of >150 mg/m2 given either as single agents or in combination with other drugs.
    • Reduced-intensity conditioning regimen: regimens with lower doses of total body irradiation, fractionated radiation therapy, busulfan, and melphalan than those used to define a myeloablative conditioning regimen (above).

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Last Updated: 5/15/2015 12:13 PM