Veno-occlusvie disease (VOD) / Sinusoidal obstruction syndrome (SOS) occurs following injury to the hepatic venous endothelium, resulting in hepatic venous outflow obstruction due to occlusion of the hepatic venules and sinusoids. This typically results in a distinctive triad of clinical signs including hepatomegaly with right upper quadrant tenderness, third space fluid retention (e.g., ascites), and jaundice with a cholestatic picture. For more information on VOD / SOS including diagnostic criteria, refer to the VOD / SOS section of the Forms Instructions Manual.

Question 48-49: Did veno-occlusive disease (VOD) / sinusoidal obstruction syndrome (SOS) develop since the date of last report?

Indicate whether VOD / SOS was diagnosed during the reporting period. If “yes,” report the date of diagnosis in question 49. If VOD / SOS persisted from the prior reporting period, indicate “no” and go to question 50.

For more information regarding reporting partial or unknown dates, see General Instructions, General Guidelines for Completing Forms.

Last modified: Jan 27, 2020

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