Question 43: New onset of acute chest syndrome:

Acute chest syndrome (ACS) is a term used to identify symptoms of chest pain, cough, fever, decreased oxygen (hypoxia), and lung infiltrates. Due to the sickling nature of red blood cells as a result of sickle cell disease, ACS may result in pulmonary infarction / emboli or viral / bacterial pneumonia. Diagnoses should be made based on clinical judgement.

Report Yes in the following scenarios:

  • There was a new onset of ACS since the date of last report.
  • ACS was diagnosed prior to HCT or in a prior reporting period, resolved, and developed in the current reporting period.

Report No in the following scenarios:

  • There was not a new onset of ACS since the date of last report.
  • ACS was diagnosed in a prior reporting period and persisted into the current reporting period.

If documentation is not clear or is unavailable to determine if ACS was present, report Unknown.

Last modified: Jul 26, 2020

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