Question 56 Did a new malignancy, myeloproliferative, or lymphoproliferative disease / disorder occur that is different from the disease / disorder for which the HCT or cellular therapy was performed? (include clonal cytogenetic abnormalities, and post-transplant lymphoproliferative disorders)

Indicate whether a new or secondary malignancy, lymphoproliferative disorder, or myeloproliferative disorder has developed. Do not report recurrence, progression, or transformation of the recipient’s primary disease (disease for which the transplant was performed), or relapse of a prior malignancy.

New malignancies, lymphoproliferative disorders, or myeloproliferative disorders include but are not limited to:

  • Skin cancers (basal, squamous, melanoma)
  • New leukemia
  • New myelodysplasia
  • Solid tumors
  • PTLD (post-transplant lymphoproliferative disorder) (report as lymphoma or lymphoproliferative disease)

The following should not be reported as new malignancy:

  • Recurrence of primary disease (report as relapse or disease progression)
  • Relapse of malignancy from recipient’s pre-HCT medical history
  • Breast cancer found in other (i.e., opposite) breast (report as relapse)
  • Post-HCT cytogenetic abnormalities associated with the pre-HCT diagnosis (report as relapse)
  • Transformation of MDS to AML post-HCT (report as disease progression)

If a new malignancy, lymphoproliferative disorder, or myeloproliferative disorder was diagnosed during the reporting period, report Yes and complete the Subsequent Neoplasms (3500) Form, which will come due.

If the new malignancy, lymphoproliferative disorder, or myeloproliferative disorder was reported in a prior reporting period, select Previously reported.

Section Updates:

Question Number Date of Change Add/Remove/Modify Description Reasoning (If applicable)
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Last modified: Sep 23, 2022

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