Questions 125-126: Specify POEMS clinical features (check all that apply):

POEMS syndrome is poorly understood, but generally refers to P olyneuropathy, O organomegaly, E ndocrinopathy, M protein, and S kin changes. Proper diagnosis is crucial for appropriate clinical management and varying clinical features help guide therapy. Indicate which clinical features, specific to POEMS only, are present at the time of diagnosis of POEMS syndrome or prior to the start of first therapy. Check all that apply. If there are other clinical features not listed in this section, select “other” in question 125, in addition to any available options that apply, and specify the other clinical feature in question 126.

Questions 127-128: Thyroid stimulating hormone (TSH):

Indicate whether the thyroid stimulating hormone (TSH) level was “known” or “unknown” at the time of POEMS diagnosis. If “known,” report the value (in mU/L) in question 128 (mU/L is equivalent to μU/mL) and continue with question 129. If “unknown,” continue with question 130.

Question 129: Upper limit of normal for thyroid stimulating hormone (TSH) level:

Indicate the upper limit of normal (in mU/L) for thyroid stimulating hormone (TSH) level from the laboratory report.

Questions 130-131: Testosterone level:

Indicate whether the testosterone level was “known” or “unknown” at the time of POEMS diagnosis. If “known,” report the value and unit of measure documented on the laboratory report in question 131 and continue with question 132. If “unknown,” continue with question 133.

Question 132: Upper limit of normal for testosterone level:

Indicate the upper limit of normal for testosterone level from the laboratory report.

Questions 133-134: Estradiol level:

Indicate whether the estradiol level was “known” or “unknown” at the time of POEMS diagnosis. If “known,” report the value (in pg/mL) in question 134 and continue with question 135. If “unknown,” continue with question 136.

Question 135: Upper limit of normal for estradiol level:

Indicate the upper limit of normal for estradiol level (in pg/mL) from the laboratory report.

Questions 136-137: Prolactin level:

Indicate whether the prolactin level was “known” or “unknown” at the time of POEMS diagnosis. If “known,” report the value (in ng/mL) in question 137 and continue with question 138. If “unknown,” continue with question 139.

Question 138: Upper limit of normal for prolactin level:

Indicate the upper limit of normal (in ng/mL) for prolactin level from the laboratory report.

Questions 139-140: Cortisol level:

Indicate whether the cortisol level was “known” or “unknown” at the time of POEMS diagnosis. If “known,” report the value and unit of measure to the nearest tenth documented on the laboratory report in question 140 and continue with question 141. If “unknown,” continue with question 142.

Question 141: Upper limit of normal for cortisol level:

Indicate the upper limit of normal for cortisol level from the laboratory report.

Questions 142-143: Interleukin-6:

Indicate whether the interleukin-6 value was “known” or “unknown” at the time of POEMS diagnosis. If “known,” report the value (in pg/mL) to the nearest tenth in question 143 and continue with question 144. If “unknown,” continue with question 145.

Question 144: Upper limit of normal for interleukin-6:

Indicate the upper limit of normal (in pg/mL) for interleukin-6 from the laboratory report.

Questions 145-146: Was pulmonary artery hypertension present?

Pulmonary hypertension (PH) refers to elevated pulmonary arterial pressure. PH can be due to primary elevation of pressure in the pulmonary arterial system alone (pulmonary arterial hypertension), or secondary to elevations of pressure in the pulmonary venous and pulmonary capillary systems (pulmonary venous hypertension; post-capillary PH). Indicate whether pulmonary artery hypertension was present at the time of POEMS diagnosis. If present, indicate “yes” and report the estimated systolic artery pressure documented on the laboratory report in question 146. If not present, indicate “no” and continue with question 147.

Questions 147-148: Forced vital capacity (FVC):

Forced vital capacity is the total amount of air exhaled during the forced expiratory volume test. FVC is a measurement taken during spirometry studies. Indicate whether the forced vital capacity percentage was “known” or “unknown” at the time of POEMS diagnosis or prior to the start of first therapy. If “known,” report the percentage documented on the pulmonary function test (PFT) in question 148. If “unknown,” continue with question 149.

Questions 149-150: Total lung capacity :

Indicate whether the total lung capacity was “known” or “unknown” at the time of POEMS diagnosis or prior to the start of first therapy. If “known,” report the value documented on the laboratory report in question 150. If “unknown,” continue with question 151.

Questions 151-152: Vascular endothelial growth factor (VEGF) serum value:

Vascular endothelial growth factor (VEGF) promotes the growth of new blood vessels and acts as a signaling protein influencing the rate at which this process is performed. Indicate whether the serum-derived vascular endothelial growth factor (VEGF) value was “known” or “unknown” at the time of POEMS diagnosis. If “known,” report the value documented on the laboratory report in question 152 and continue with question 153. If “unknown,” continue with question 154.

Question 153: Upper limit of normal for vascular endothelial growth factor (VEGF) serum value:

Indicate the upper limit of normal for serum-derived vascular endothelial growth factor (VEGF) value from the laboratory report.

Questions 154-155: Vascular endothelial growth factor (VEGF) plasma value:

Vascular endothelial growth factor (VEGF) promotes the growth of new blood vessels and acts as a signaling protein influencing the rate at which this process is performed. Indicate whether the plasma-derived vascular endothelial growth factor (VEGF) value was “known” or “unknown” at the time of POEMS diagnosis. If “known,” report the value documented on the laboratory report in question 155 and continue with question 156. If “unknown,” continue with question 157.

Question 156: Upper limit of normal for vascular endothelial growth factor (VEGF) plasma value:

Indicate the upper limit of normal for plasma-derived vascular endothelial growth factor (VEGF) value from the laboratory report.

Section Updates:

Question Number Date of Change Add/Remove/Modify Description Reasoning (If applicable)
. . . . .
Last modified: Dec 22, 2020

Need more help with this?
Don’t hesitate to contact us here.

Was this helpful?

Yes No
You indicated this topic was not helpful to you ...
Could you please leave a comment telling us why? Thank you!
Thanks for your feedback.