The response time for POEMS tends to occur well after transplant, so the “best response” to transplant may not occur within the first 100 days. The intent of this question is to determine the best overall response to HCT or cellular therapy, which could include any response to planned therapy post-HCT or post-cellular therapy, or to therapy given for maintenance or prophylaxis. DO NOT include any response to treatment given for relapsed or progressive disease. This is assessed in each reporting period. When evaluating the best response, determine the disease status within the reporting period and compare it to all previous post-HCT or post-cellular therapy reporting periods. If the response in the current reporting period is the best response to date, report the disease status established within this reporting period. If a better response was established in a previous reporting period, report the previously established disease status.

Questions 110-111: Specify POEMS clinical features at the time of best response (check all that apply):

Indicate which clinical features, specific to POEMS only, are present at the time of best response. Check all that apply. If there are other clinical features not listed in this section, select “other” in question 110, in addition to any available options that apply, and specify the other clinical feature in question 111.

Questions 112-113: Thyroid stimulating hormone (TSH):

Indicate whether the thyroid stimulating hormone (TSH) level was “known” or “unknown” at the time of best response. If “known,” report the value (in mU/L) in question 113 (mU/L is equivalent to μU/mL) and continue with question 114. If “unknown,” continue with question 115.

Question 114: Upper limit of normal for thyroid stimulating hormone (TSH) level:

Indicate the upper limit of normal (in mU/L) for thyroid stimulating hormone (TSH) level from the laboratory report.

Questions 115-116: Testosterone level:

Indicate whether the testosterone level was “known” or “unknown” at the time of best response. If “known,” report the value and unit of measure documented on the laboratory report in question 116 and continue with question 117. If “unknown,” continue with question 118.

Question 117: Upper limit of normal for testosterone level:

Indicate the upper limit of normal for testosterone level from the laboratory report.

Questions 118-119: Estradiol level:

Indicate whether the estradiol level was “known” or “unknown” at the time of best response. If “known,” report the value (in pg/mL) in question 119 and continue with question 120. If “unknown,” continue with question 121.

Question 120: Upper limit of normal for estradiol level:

Indicate the upper limit of normal (in pg/mL) for estradiol level found on the laboratory report.

Questions 121-122: Prolactin level:

Indicate whether the prolactin level was “known” or “unknown” at the time of best response. If “known,” report the value (in ng/mL) in question 122 and continue with question 123. If “unknown,” continue with question 124.

Question 123: Upper limit of normal for prolactin level:

Indicate the upper limit of normal (in ng/mL) for prolactin level found on the laboratory report.

Questions 124-125: Cortisol level:

Indicate whether the cortisol level was “known” or “unknown” at the time of best response. If “known,” report the value and unit of measure to the nearest tenth documented on the laboratory report in question 125 and continue with question 126. If “unknown,” continue with question 127.

Question 126: Upper limit of normal for cortisol level:

Indicate the upper limit of normal for cortisol level found on the laboratory report.

Questions 127-128: Interleukin-6:

Indicate whether the interleukin-6 value was “known” or “unknown” at the time of best response. If “known,” report the value (in pg/mL) to the nearest tenth in question 128 and continue with question 129. If “unknown,” continue with question 130.

Question 129: Upper limit of normal for interleukin-6:

Indicate the upper limit of normal for interleukin-6 found on the laboratory report.

Questions 130-131: Was pulmonary artery hypertension present?

Pulmonary hypertension (PH) refers to elevated pulmonary arterial pressure. PH can be due to primary elevation of pressure in the pulmonary arterial system alone (pulmonary arterial hypertension), or secondary to elevations of pressure in the pulmonary venous and pulmonary capillary systems (pulmonary venous hypertension; post-capillary PH). Indicate whether pulmonary artery hypertension was present at the time of best response. If present, select “yes” and report the estimated systolic artery pressure documented on the laboratory report in question 131. If not present, report “no” and continue with question 132.

Questions 132-133: Forced vital capacity (FVC):

Forced vital capacity is the total amount of air that can be exhaled during the forced expiratory volume test. FVC is a measurement taken during spirometry studies. Indicate whether the forced vital capacity percentage was “known” or “unknown” at the time of best response. If “known,” report the percentage documented on the pulmonary function test (PFT) in question 133. If “unknown,” continue with question 134.

Questions 134-135: Total lung capacity:

Indicate whether the total lung volume was “known” or “unknown” at the time of best response. If “known,” report the value documented on the pulmonary function report in question 135. If “unknown,” continue with question 136.

Questions 136-137: Vascular endothelial growth factor (VEGF) serum value:

Vascular endothelial growth factor (VEGF) promotes the growth of new blood vessels and acts as a signaling protein influencing the rate at which this process is performed. Indicate whether the serum-derived vascular endothelial growth factor (VEGF) value was “known” or “unknown” at the time of best response. If “known,” report the value documented on the laboratory report in question 137 and continue with question 138. If “unknown,” continue with question 139.

Question 138: Upper limit of normal for vascular endothelial growth factor (VEGF) serum value:

Indicate the upper limit of normal for serum-derived vascular endothelial growth factor (VEGF) value found on the laboratory report.

Questions 139-140: Vascular endothelial growth factor (VEGF) plasma value:

Vascular endothelial growth factor (VEGF) promotes the growth of new blood vessels and acts as a signaling protein influencing the rate at which this process is performed. Indicate whether the plasma-derived vascular endothelial growth factor (VEGF) value was “known” or “unknown” at the time of best response. If “known,” report the value documented on the laboratory report in question 140 and continue with question 141. If “unknown,” continue with question 142.

Question 141: Upper limit of normal for vascular endothelial growth factor (VEGF) plasma value:

Indicate the upper limit of normal for plasma-derived vascular endothelial growth factor (VEGF) value found on the laboratory report.

Section Updates:

Question Number Date of Change Add/Remove/Modify Description Reasoning (If applicable)
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Last modified: Dec 22, 2020

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