If the indication for HCT is due to a combination of diseases or a transformation of one disease to another, it may be necessary to report multiple disease classifications. The tables below list how common examples of disease combinations and transformations should be reported using the Disease Classification questions.

Common Disease Combinations

Disease Combinations Report Primary Disease as: Report disease diagnosis date of: Complete multiple disease sections of the Disease Classification Form?
FAN or SAA and AML AML AML No
FAN or SAA and MDS MDS MDS No
MYE and AMY MYE MYE No

Common Disease Transformations

Disease Transformation Report primary disease as: Report disease diagnosis date of: Complete multiple disease sections of the Disease Classification Form?
MDS or MPN to AML AML AML Yes – AML and MDS or MPN
JMML to AML AML AML Yes – AML and MDS (select questions only)
NHL to another NHL Second NHL diagnosis Second NHL diagnosis No
HL to NHL* NHL NHL No
CLL to NHL (i.e., Richter’s Syndrome) NHL NHL No

AML=Acute Myelogenous Leukemia; AMY=Amyloidosis; CLL=Chronic Lymphocytic Leukemia; FAN=Fanconi Anemia; MDS=Myelodysplastic Syndrome; MPS=Myeloproliferative Disease; MYE=Multiple Myeloma; NHL=Non-Hodgkin Lymphoma; SAA=Severe Aplastic Anemia.
*Ensure that the disease process is a transformation from Hodgkin lymphoma to Non-Hodgkin lymphoma (typically diffuse large B-cell lymphoma), rather than the distinct entity “B-cell lymphoma, unclassifiable, with features indeterminate between DLBCL and classical Hodgkin Lymphoma.”

Question 1: Date of diagnosis for primary disease for HCT:

The date of diagnosis is important because the interval between diagnosis and HCT is often a significant indicator for the recipient’s prognosis post-HCT. Refer to the disease-specific section of the Disease Classification (2402) manual for guidelines when reporting the diagnosis date for each disease.

If the recipient was diagnosed prenatally (in utero) or was diagnosed with a congenital immunodeficiency, report the date of birth as the date of diagnosis.

If this is a subsequent HCT for a new malignancy (or other new indication), report the date of diagnosis of the new malignancy.

If the exact diagnosis date is not known, use the process described in General Instructions, Guidelines for Completing Forms.

Question 2: What was the primary disease for which the HCT was performed?

Select the primary disease for which the recipient is receiving the HCT and continue with the appropriate disease classification questions.

Section Updates:

Question Number Date of Change Add/Remove/Modify Description Reasoning (If applicable)
. . . . .
Last modified: Sep 23, 2022

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