Question 1: Did the donor receive growth and mobilizing factors, prior to any stem cell harvest, to enhance the product collection for this HCT? (Allogeneic donors only)
Stem cells do not typically circulate in the blood stream. Therefore, in order to increase the quantity of cells for collection, an agent is frequently given to the allogeneic donor. The purpose of the agent is to move the stem cells from the bone marrow into the peripheral blood where the cells can be collected by apheresis. This practice is often referred to as mobilization or priming. Occasionally, a donor may be primed using a growth factor prior to collection of bone marrow.
If the Allogeneic donor received therapy (such as growth factors, mobilizing agents, etc.), select “yes” and continue with question 2.
If the Allogeneic donor did not receive therapy to enhance the stem cell product, select “no” and continue with question 4.
This question is only enabled for PBSC and bone marrow products from non-NMDP donors.
Questions 2-3: Specify growth and mobilizing factor(s)
Examples of growth and mobilizing factors include, but are not limited to, the following:
Epidermal growth factor – EGF
Erythropoietin – EPO
Fibroblast growth factor – FGF
Granulocyte-colony stimulating factor – G -CSF
Granulocyte-macrophage colony stimulating factor – GM-CSF
Growth differentiation factor-9 – GDF9
Hepatocyte growth factor – HGF
Insulin-like growth factor – IGF
Platelet-derived growth factor – PDGF
Thrombopoietin – TPO
Transforming growth factor alpha – TGF-α
Transforming growth factor beta – TGF-β
Report if any of the following growth or mobilizing factors were given. Check all that apply.
G-CSF (granulocyte-colony stimulating factor, filgrastim, Neupogen®)
Pegylated G-CSF (pegfilgrastim, Neulasta®)
If a growth or mobilizing factor was given is not included in the above list, select “other growth or mobilizing factor(s)” for question 2 and specify the generic name for the growth or mobilizing factor in question 3.
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