Question 108-109: Did engraftment syndrome occur?
Engraftment syndrome typically occurs during neutrophil recovery post-HCT and is characterized by capillary leak syndrome, non-infectious fever, erythrodermatous skin rash, and non-cardiogenic pulmonary edema. Engraftment syndrome is usually seen following autologous transplants, but can occur after allogeneic transplants. It is associated with increased transplant mortality, generally from pulmonary and associated multi-organ failure. Corticosteroid therapy is often an effective treatment for engraftment syndrome, mainly for the treatment of pulmonary symptoms.
Indicate whether the recipient developed engraftment syndrome.
If the recipient developed engraftment syndrome during the reporting period, report “yes” and indicate the date of diagnosis in question 109. If the recipient did not develop engraft syndrome, report “no” and continue with question 131.
For more information regarding reporting partial or unknown dates, see General Instructions, General Guidelines for Completing Forms.
Question 110-119: Specify symptoms of engraftment syndrome
Indicate whether the recipient developed the symptoms listed. If “other symptom” is selected, specify symptom in question 119.
Question 120: Was a biopsy performed?
If a biopsy was performed to evaluate engraftment syndrome, report “yes” and specify the site(s) in questions 121-125. If no biopsies were done to evaluate for engraftment syndrome, report “no” and continue with question 126.
Question 121-125: Specify site:
From the options listed, report the biopsy site. If “other site” is selected, specify the location of the biopsy in question 124. Indicate whether documentation (pathology report) was attached to the form in FormsNet3 or otherwise submitted to the CIBTMR in question 125. For further instructions on how to attach documents in FormsNet3, refer to the training guide.
Question 126: Was therapy given for engraftment syndrome?
Report if therapy was given for engraftment syndrome. If therapy was given for engraftment syndrome, report “yes” and continue with question 127. If therapy was not given, report “no” and continue with question 130.
Question 127-129: Specify therapy given for engraftment syndrome (systemic corticosteroids, other therapy)
Report any treatment given for engraftment syndrome. If “other therapy” is chosen, specify the treatment(s) in question 129.
Question 130: Did engraftment syndrome resolve?
Indicate whether engraftment syndrome resolved during the reporting period. If engraftment syndrome was still present on the date of contact, report “no.”
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