Welcome to the CIBMTR Forms Instruction Manual. The Table of Contents on the left side of the screen is for navigational purposes; if you are on a mobile device you may find the Table on Contents on the top of the page.

General Instructions provides useful general background information for successfully completing forms.

2804/2814: CRID Assignment and Indication provides explanatory text used to generate a CIBMTR Research ID (CRID) and report the indication.

Transplant Essential Data (TED) Manuals provides explanatory text for each question found on the TED forms.

Comprehensive Baseline & Follow-up Forms Manuals provides explanatory text for each question on the Baseline, Follow-up, IDMs, HLA, and Infusion forms.

Comprehensive Disease Specific Manuals provides explanatory text and additional information for disease indications requiring CIBMTR reporting.

Cellular Therapy Manuals provides explanatory text for completing pre-infusion, infusion, and post-infusion forms

Infection & Miscellaneous Manuals provides explanatory text for manuals such as the Hepatitis Serology, VOD / SOS, and Myelofibrosis CMS Study forms.

Appendices provide additional information beyond the scope of the other manuals.

Manual Updates:
Sections of the Forms Instruction Manual are frequently updated. In addition to documenting the changes within each manual section, the most recent updates to the manual can be found below. For additional information, select the manual section and review the updated text.

Date Manual Section Add/Remove/Modify Description
8/29/2019 4006: Product Identification Modify Updated instruction in pink warning box above question 17: Question 17-45: Reporting total number of cells
Report the total number of cells (not cells per kilogram) contained in the product administered not corrected for viability.
8/14/2019 4000: Cellular Therapy and HCT History Modify Updated instruction for question 24: If “yes”, continue to question 29. If “no”, continue with question 25. If “unknown”, questions 25, 26, and 28 are optional and you can continue to question 23.
8/14/2019 4000: Cellular Therapy and HCT History Modify Updated instruction for question 15: If “yes”, continue to question 23. If “no”, continue with question 16. If “unknown”, questions 16, 17, 18, and 22 are optional and you can continue to question 23.
8/2/19 2820: Recipient Contact Information Modify Version 2 of the 2820: Recipient Contact Information section of the Forms Instructions Manual released. Version 2 corresponds to revision 2 of the Form 2820.
7/3/19 2400: Pre-TED Modify Updated (new text in red and removed text struck out below) the blue note box under question 40 regarding Haploidentical donors:
Haploidentical Donors
A HLA-haploidentical donor is one who shares, by common inheritance, exactly one HLA haplotype with the recipient and is mismatched for a variable number of HLA genes, ranging from zero one to five, on the unshared haplotype. Potential HLA-haploidentical donors include biological parents; biological children; full or half siblings; and even extended family donors such as aunts, uncles, nieces, nephews, cousins, or grandchildren. Indicate HLA-mismatched relative” for question 40 if a haploidentical donor was used for the HCT.
6/27/19 4006: Cellular Therapy Infusion Modify Added additional information to the manual providing specific reporting instructions for commercially available products.
6/27/19 4003: Cellular Therapy Product Modify Added additional information to the manual providing specific reporting instructions for commercially available products.
6/27/19 4000: Cellular Therapy Essential Data Pre-Infusion Modify Added additional information to the manual providing specific reporting instructions for commercially available products.
6/17/19 2400: Pre-TED Modify Added additional information (in red below) to the instructional text for question 40 to better define the related donor types listed on the form:
Indicate the relationship and match between the recipient and the donor. Only consider HLA-A, B, C, and DRB1 when determining the donor’s match / mismatched relationship to the recipient.
  • Syngeneic:
    • Includes: Monozygotic (identical) twins. Occurs when a single egg is fertilized to form one zygote, which then divides into two separate embryos.
    • Does not include: Other types of twins or HLA-identical siblings (see below).
  • HLA-identical sibling:
    • Includes: Non-monozygotic (dizygotic, fraternal, non-identical) twins. Occurs when two eggs are fertilized by two different sperm cells at the same time. This category also includes siblings who aren’t twins, but have identical HLA types. The patient and donor will be allele-level matched at HLA-A, B, C, and DRB-1.
    • Does not include: Half-siblings (report as “HLA matched other relatives” if their HLA is a match, or “mismatched relative” if it does not match).
  • HLA-matched other relative:
    • Includes: All blood-related relatives, other than siblings, who are HLA matched (e.g., parents, aunts, uncles, children, cousins, half-siblings). The patient and donor will be allele-level matched at HLA-A, B, C, and DRB1.
    • Does not include: Adoptive parents/children or stepparents/children who are HLA matched.
  • HLA-mismatched relative:
    • Includes: Siblings who are not HLA-identical and all other blood-related relatives who have at least one HLA mismatch (e.g., parents, aunts, uncles, children, cousins, half-siblings). This includes haploidentical donors. The patient and donor will be allele-level mismatched at one or more loci (HLA-A, B, C, or DRB1).
    • Does not include: Adoptive parents/children or stepparents/children.
5/14/2019 F4100 Cellular Therapy Essential Data Follow-up Remove Removed note box Survival status For scenarios where both HCT and CT forms will be submitted at the same time, there are duplicate questions across the F2100 and F4100. To reduce the reporting burden, duplicated questions on the Cellular Therapy forms are disabled. This includes Survival Status reported on F4100.
Last modified: 2019/08/29

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