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Immunobiology Working Committee Studies

The Immunobiology Working Committee provides scientific oversight for studies related to histocompatibility and other genetic and immunologic issues related to hematopoietic cell transplantation.

Learn more about the studies conducted through the Immunobiology Working Committee using the links below.

Recently Completed Studies

NumberTitleStatus
IB14-05 Mitochondrial deoxyribonucleic acid haplotypes and unrelated donor transplant outcomes. Published
IB14-04 Assessing the similarity of the T cell receptor repertoire in allogeneic hematopoietic stem cell recipients with the same single human leukocyte mismatches. Published
IB14-03d The clinical and functional effects of TERT variants in MDS Published
IB14-03c Impact of telomere length and telomerase gene mutations on allogeneic stem cell transplantation outcomes in myelodysplastic syndrome. Published
IB14-03a The prognostic impact of levels of CXC chemokine ligands on post hematopoietic cell transplantation outcomes in patients with myelodysplastic syndromes. Published
IB12-04b Effect of HLA-C allele matching in the context of recipient HLA-C-encoded KIR ligand grouping (C1 or C2) on the outcome of unrelated hematopoietic stem cell transplantation (HSCT) Published
IB12-04 Determining the effects of human leukocyte antigen-C killer-cell immunoglobulin-like receptors ligand expression on outcomes of unrelated hematopoietic stem cell transplantation. Published
IB11-05b Killer-cell immunoglobulin-like receptors genotyping and Immune function in myelodysplastic syndrome patients prior to unrelated donor transplantation. Published
IB10-01k DNA-methylation-based telomere length estimator: Comparisons with measurements from flow FISH and qPCR Published
IB10-01j Genome-wide association study identifies human leukocyte antigen-DPB1 as a significant risk factor for sever aplastic anemia. Published
IB10-01i Population frequency of fanconi pathway gene variants and their association with survival after hematopoietic cell transplant for severe aplastic anemia. Published
IB10-01h Pre-transplant short telomeres are associated with high mortality risk after unrelated donor haematopoietic cell transplant for severe aplastic anemia. Published
IB10-01f Epigenetic clock: Can this guide donor selection in hematopoietic stem cell transplantation. Published
IB10-01c Telomere length telomerase polymorphism in severe aplastic anemia - exome analysis and mosaicism. Published
IB09-06s Validation of genetic associations with acute graft versus host disease and nonrelapse mortality in DISCOVeRY-BMT. Published
IB09-06p Genetics and epidemiology of myeloid malignancies genome-wide association study. Published
IB09-06h DISCOVeRY-BMT: Recipient, donor genome-wide association study. Published
IB09-06g DISCOVeRY-BMT: Recipient, donor, recipient-donor sharing, genome-wide association study (acute lymphoblastic leukemia only). Published
IB09-06f Case-control study of acute myelogenous leukemia exome and genome-wide association study. Published
IB09-06e DISCOVeRY-BMT: Exome analysis, 10/10 unrelated donors, recipient, donor, recipient-donor shared. Published
IB06-13
R04-80s 		Impact of allele-level human leukocyte antigen matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy. Published
IB06-05d HLA-B leader and survivorship after HLA-mismatched unrelated donor transplantation Published
IB06-05c Role of HLA-DP expression in graft-versus-host disease after unrelated donor transplantation Published
IB06-05b Human leukocyte antigen-C expression levels define permissible mismatches in hematopoietic cell transplantation. Published
IB05-02
IB07-07 		Impact of human leukocyte antigen-DR15 on clinical outcomes after unrelated hematopoietic cell transplantation. Published
R02-40
R03-63i 		Following Transplantation for Acute Myelogenous Leukemia, Donor KIR Cen B02 Better Projects against Relapse than KIR Cen B01 Published
R02-40
R03-63h 		Killer-cell immunoglobulin-like receptors B donors improve the outcome for acute myeloid (myelogenous) leukemia patients given reduced intensity conditioning and unrelated donor transplant. Published
IB19-01a The impact of ultra-high resolution human leukocyte antigen matching on the outcome of unrelated donor hematopoietic cell transplantation. Published
IB18-06b Clonal mosaicism and hematopoietic stem cell transplantation outcomes in patients with acute myelogenous leukemia. Published
IB18-06a Clonal mosaicism and hematopoietic stem cell transplantation outcomes in patients with acute lymphoblastic leukemia. Published
IB18-04a Evaluation of the impact of donor killer immunoglobulin receptor genotype on outcome after unrelated donor transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia. Published
IB18-03 The effect of human leukocyte antigen class I heterozygosity and human leukocyte antigen supertypes on outcomes following allogeneic hematopoietic cell transplant for myeloid and lymphoid malignancies. Published
IB18-01 Effect of human leukocyte antigen phenotypes on long term graft versus host disease risk. Published
IB17-02 Donor-recipient natural killer cell determinants associated with survival in juvenile myelomonocytic leukemia after hematopoietic stem cell transplantation. Published
IB16-03 Role of recipient and donor genetic polymorphisms in interferon lambda 4 on outcomes after unrelated allogeneic cell transplant. Published
IB16-01 The role of human leukocyte antigen-E compatibility in the prognosis of acute leukemia patients undergoing 10/10 human leukocyte antigen matched unrelated hematopoietic stem cell transplant. Published
IB15-07 Functional genetic variants of the ST2 gene in pairs of recipient and donors for risk stratification of graft versus host disease and treatment-related mortality/transplant-related mortality outcomes. Published
IB15-04 Clinical outcomes among hematopoietic stem cell transplant recipients as a function of socioeconomic status and related transcriptome differences. Published
IB15-03 Killer immunoglobulin receptor gene content and pediatric acute leukemia transplant outcomes. Published

Preliminary Results

NumberTitleStatus
IB09-06n Compare unrelated donor to welcome trust case control consortium controls. Submitted
IB09-06b Genetic susceptibility to transplant-related mortality after unrelated donor stem cell transplant. Submitted
R04-74c Donor KIR3DL1 and HLA-B subtypes and leukemia control in HLA-compatible allogeneic hematopoietic stem cell transplantation Submitted
IB20-02 Evaluation of the impact of human leukocyte antigen molecular mismatch on clinical outcomes in patients who underwent haploidentical hematopoietic stem cell transplantation. Submitted
SC19-07 A Novel KIR-HLA Interaction Scoring System and its Effect on Transplantation Outcomes after HLA Matched Allogeneic Hematopoietic Stem Cell Transplantation Submitted
IB14-07 Indirectly recognizable human leukocyte antigen epitopes: A retrospective validation study on the role of indirect recognition of mismatched human leukocyte antigen in hematopoietic stem cell transplantation outcome. Manuscript Preparation
IB13-09 The development of machine learning based classifiers to define the alloreactivity of HLA mismatches in unrelated donor hematopoietic stem cell transplantation Manuscript Preparation
IB11-01 Analysis of the NIMA effect on the outcome of unrelated PBSC/BM transplantation Manuscript Preparation
IB09-06o Genetics and epidemiology of myeloid malignancies candidate gene paper. Manuscript Preparation
IB09-06m Analysis of X chromosome single nucleotide polymorphisms. Manuscript Preparation
IB09-06j Additional analysis of major histocompatibility complex single nucleotide polymorphisms. Manuscript Preparation
RT09-04
IB09-06i 		Recipient, donor genome-wide association study interaction with conditioning intensity (myeloablative/reduced intensity conditioning), total body irradiation, disease status. Manuscript Preparation
IB20-01 Association of immunopeptidome divergence between mismatched human leukocyte antigen class I alleles and outcome of 9/10 matched unrelated hematopoietic stem cell transplant. Manuscript Preparation
SC19-06 An Unbiased Data-Driven Approach for Identification of Optimal KIR/HLA HCT Donors Manuscript Preparation
IB19-04 Impact of donor human leukocyte antigen on transplant outcomes in NPM1 mutated acute myeloid leukemia. Manuscript Preparation
IB19-03 Impact of the direction of natural killer cell alloreactivity predicted by KIR ligand mismatch on engraftment in umbilical cord blood and haploidentical stem cell transplantation. Manuscript Preparation
IB19-02b The role of human leukocyte antigen-B leader dimorphism on outcome after haploidentical hematopoietic stem cell transplant. Manuscript Preparation
IB19-02a Effect of class II human leukocyte antigen mismatching on the outcome of human leukocyte antigen haploidentical hematopoietic cell transplantation with high dose, post-transplantation cyclophosphamide: A combined CIBMTR/EBMT analysis. Manuscript Preparation
IB19-01b Refinement of the T cell epitope algorithm for the definition of permissive human leukocyte antigen-DPB1 mismatches in allogeneic hematopoietic cell transplantation: Stratification of T cell epitope group 3 mismatches. Manuscript Preparation
IB18-02 The impact of human leukocyte antigen class I risk alleles associated with aplastic anemia immune pathogenesis on allogeneic transplant outcomes in patients with severe acquired aplastic anemia. Manuscript Preparation
IB17-04 Epigenetic profiling of unrelated donor-recipient pairs to improve donor selection during hematopoietic stem cell transplants. Manuscript Preparation

Studies in Progress

NumberTitleStatus
IB12-02d Refinement of the T cell epitope algorithm for the definition of permissive HLA-DPB1 mismatches in allogeneic hematopoietic cell transplantation: stratification of TCE group 3 mismatches. Analysis
IB20-03 Donor socioeconomic status as a predictor of altered immune function and treatment response following hematopoietic cell transplantation for hematologic malignancy Analysis
SC19-13 Evaluation of the impact of HLA Class I and II mismatches potentially non-immunogenic mismatches Analysis
IB18-07 Donor and recipient genomic associations with acute graft-vs-host disease. Analysis
IB18-04b Evaluation of the impact of donor killer immunoglobulin receptor genotype on outcome after unrelated donor transplantation in patients with myelodysplastic syndromes or acute myeloid leukemia. Analysis
IB17-03 Identification of genomic markers of post hematopoietic cell transplantation outcomes in patients with myelofibrosis: A pilot study. Analysis
IB16-02 Use of human leukocyte antigen structure and function parameters to understand the relationship between human leukocyte antigen disparity and transplant outcomes. Analysis
IB21-01 Effect of HLA evolutionary divergence on survival and relapse following allogeneic hematopoietic cell transplant Protocol Development
IB09-07 Clinical significance of genome-wide variation in unrelated HCT Ongoing
IB09-05 Identification of functional single nucleotide polymorphisms in umbilical cord blood transplantation Ongoing
IB09-03 Clinical relevance of cytokine/immune response gene polymorphisms in umbilical cord blood transplantation Ongoing
IB09-01
IB09-03
IB09-05
IB09-07 		Clinical importance of minor histocompatibility complex haplotypes in umbilical cord blood transplantation. Ongoing
IB09-01 Clinical importance of minor histocompatibility complex haplotypes in umbilical cord blood transplantation Ongoing
R04-74f Functional significance of killer cell immunoglobulin-like receptor genes in human leukocyte antigen-matched and mismatched unrelated hematopoietic cell transplantation Ongoing
R02-40
R03-63e 		Recipient HLA-C1 enhances the clinical advantage of killer-cell immunoglobulin-like receptor B haplotype donors in unrelated transplantation for acute myelogenous leukemia Ongoing

Last Updated: 10/22/2020 1:37 PM
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