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CIBMTR supports investigators in conducting observational studies in hematopoietic cell transplantation (HCT) and ceulllar therapies. Anyone willing to actively participate in the conduct of the study and follow the study development and management process may propose a study using the
Study Proposal Outline. We encourage you to use this
Word template when submitting your proposal.
Prior to submitting a proposal, we strongly encourage investigators to review:
This information will assist you in identifying existing research variables and avoid duplication of works already accomplished or those in progress.
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The proposal is submitted to the CIBMTR Coordinating Center at
by November 15 to guarantee discussion during the upcoming TCT Working Committee Meetings. A proposal number is assigned, and the proposal is forwarded to the Working Committee Scientific Director and the MS-level Statistician who reviews the proposal for feasibility with CIBMTR data and potential conflict with active studies. The MS-level Statistician then forwards the proposal to the Working Committee Chairs for discussion.
The Working Committee Leadership reviews all proposals for scientific merit, feasibility, overlap with other studies and CIBMTR's ability to complete the study in a timely fashion. If duplication is identified, the proponent may be asked to join the Writing Committee of an ongoing study.
In advance of the February TCT Tandem Meetings, the Working Committee MS biostatistician prepares a table of characteristics of patient data based on the population defined in the proposal. This information is used during the presentation at the Working Committee meeting.
Once cleared to move forward, the MS biostatistician contacts the investigator; all investigators are encouraged to personally present their proposals to the full Working Committee each February.
After presentation and discussion, Working Committee members vote for each proposal, assigning a scientific impact score to each.
NOTE: Most proposals will follow this path. However, in special circumstances, a proposal deemed of high merit may be forwarded directly to the Working Committee ("fast tracked") for consideration at another time of the year.
Feedback from Working Committee Meetings at the annual meeting is considered in deciding the relative merits of proposals. Final decisions regarding which studies to pursue are made by the Working Committee Chairs and after Advisory Committee approval of the complete CIBMTR research agenda.
Investigators are notified within approximately one month of the TCT Working Committee Meeting.
Note: Within the last 5 years, the CIBMTR acceptance proposal rate has been 20-25%.
NOTE: If the study requires biological samples from the Research Sample Repository, in addition to the review process described here, investigators must include a biosketch or brief curriculum vitae documenting experience in the laboratory methods proposed. The NMDP/Be The Match Institutional Review Board must also review proposed studies before samples can be distributed.