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Our Immunobiology Research Program facilitates CIBMTR Immunobiology Working Committee (IBWC) studies that use samples from the Research Sample Repository (cell and serum samples collected by the National Marrow Donor Program® (NMDP)/Be The Match from related and unrelated transplant donors, cord blood units and recipients). The IBWC seeks proposals for studies that are highly translational and hypothesis-driven. Such studies usually seek to define the clinical importance of the immune system using HCT as the model system.
Immunobiology-focused research is conducted through the IBWC utilizing samples from the NMDP Research Sample Repository.
The Donor/Recipient Pair Project is a retrospective typing project to characterize class I (HLA-A, B and C) and class II (HLA-DRB, DQB1 and DPB1) alleles and KIR genotypes of stored donor/recipient paired samples from the NMDP Repository. To date, more than 32,000 paired samples have been characterized for HLA (~80% include DPB1) and over 18,000 for KIR. The resultant data are stored in an NMDP/Be The Match-developed database and available to any researcher with a CIBMTR-approved study that wishes to analyze the impact of HLA matching or KIR genotype as either the focus of, or as a variable in a research study. The allele-level data are also used to assess genetic diversity within the NMDP/Be The Match transplant population and have focused on the evaluation of HLA haplotypes within the donor and recipient data set.