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Our Immunobiology Research Program facilitates CIBMTR Immunobiology Working Committee (IBWC) studies that use samples from the Research Sample Repository (cell and serum samples collected by the National Marrow Donor Program® (NMDP)/Be The Match from related and unrelated transplant donors, cord blood units and recipients). The IBWC seeks proposals for studies that are highly translational and hypothesis-driven. Such studies usually seek to define the clinical importance of the immune system using HCT as the model system.
Immunobiology-focused research is conducted through the IBWC utilizing samples from the NMDP Research Sample Repository.
The Donor/Recipient Pair Project is a retrospective typing project to characterize class I (HLA-A, B and C) and class II (HLA-DRB, DQB1 and DPB1) alleles and KIR genotypes of stored donor/recipient paired samples from the NMDP Repository. To date, more than 16,000 paired samples have been fully characterized for HLA and over 1,000 for KIR. The resultant data are stored in an NMDP/Be The Match-developed database and available to any researcher with a CIBMTR-approved study that wishes to analyze the impact of HLA matching or KIR genotype as either the focus of, or as a variable in a research study. The allele-level data are also used to assess genetic diversity within the NMDP/Be The Match transplant population and have focused on the evaluation of HLA haplotypes within the donor and recipient data set.