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 BMT CTN Protocols

The Blood and Marrow Transplant Clinical Trials Network (BTM CTN) offers a range of multi-institutional Phase II and III clinical trial protocols focused directly on improving survival for patients undergoing hematopoietic cell transplantation (HCT). Learn more about these protocols through the links below

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Name ​Title
​1201A Randomized Double-Blind Phase III Study of Ibrutinib During and Following Autologous Stem Cell Transplantation Versus Placebo in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma of the Activated B-cell Subtype
​1502​Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (CHAMP)
1503​​A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults with Severe Sickle Cell Disease
​1506​A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Trial of the FLT3 Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients with FLT3/ITD AML
​1507Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease
​1601A Randomized Phase III Trial of Consolidation with Autologous Hematopoietic Cell Transplantation Followed by Maintenance Rituximab vs. Maintenance Rituximab Alone for Patients with Mantle Cell Lymphoma in Minimal Residual Disease-Negative First Complete Remission

Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation


​BMT CTN 1703 - A Randomized, Multicenter, Phase III Trial of Tacrolimus/Methotrexate versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation


​Composite Health Assessment Model for Older Adults: Applying Pre-transplant Comorbidity, Geriatric Assessment, and Biomarkers to Predict Non-Relapse Mortality after Allogeneic Transplantation


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Name ​Title
0101 Fluconazole versus Voriconazole after Allogeneic Transplantation
0102 Autologous/Autologous versus Autologous/Allogeneic Transplantation for Multiple Myeloma
0201 Peripheral Blood versus Bone Marrow Grafts from Unrelated Donors
0202 Autologous versus Nonmyeloablative Allogeneic Transplantation for Follicular Lymphoma
​0301 Conditioning Regimens in Unrelated Donor Transplantation for Aplastic Anemia
0302 Randomized Trial of Acute GVHD Therapies
0303 T-Cell Depleted Peripheral Blood Stem Cell Transplantation for AML
0401 Rituxan/BEAM versus Bexxar/BEAM with Autologous Transplantation in Diffuse Large Cell Lymphoma
0402 0402Tacrolimus/Sirolimus versus Tacrolimus/Methotrexate as GVHD Prophylaxis
0403 Etanercept for Idiopathic Pneumonia Syndrome
0501 Single versus Double Cord Blood Transplantation in Children
0502 Reduced-Intensity Conditioning in Transplantation for AML in the Elderly
​0601 Transplantation Using Reduced-Intensity Conditioning and Unrelated Donor Graft for Children with Severe Sickle Cell Disease
0603 Haploidentical Transplantation with Reduced-Intensity Conditioning
0604 Double Cord Blood Transplantation with Reduced-Intensity Conditioning
0701 Transplantation using Reduced-Intensity Conditioning for Relapsed Follicular Lymphoma
​0702 Autologous Transplantation with/without Consolidation versus Tandem Autologous Transplantation with Lenalidomide Maintenance
Continued Long-Term Follow-Up and Lenalidomide Maintenance Therapy for Patients Who Have Enrolled on BMT CTN 0702
0703 Tandem Autologous Transplantation for Recurrent Hodgkin Disease
0704 Maintenance Therapy with CC-5013 or Placebo Following Autologous Stem Cell Transplantation for Multiple Myeloma
​0801 Randomized Trial using Sirolimus with Other Agents for Chronic GVHD
0802 Corticosteroids with Mycophenolate Mofetil versus Corticosteroids with Placebo as Initial Systemic Treatment of Acute GVHD
​0803 High Dose Chemotherapy with Autologous Stem Cell Rescue for Aggressive B cell Lymphoma and Hodgkin Lymphoma in HIV-infected Patients
​0804 Phase II Study of Reduced-intensity Allogeneic Stem Cell Transplantation for High Risk Chronic Lymphocytic Leukemia
​0805 Hyper-CVAD and Dasatinib with or without Allogeneic Stem Cell transplant in Patients with Philadelphia (Ph) Chromosome Positive and/or Bcr-Abl Positive Acute Lymphoblastic Leukemia​
​0901 Myeloablative versus Nonmyeloablative Transplant Conditioning in Patients with Myelodysplastic Syndrome or Acute Myelogenous Leukemia
0902 Peri-transplant Stress Management
0903 Allogeneic Hematopoietic Cell Transplant for Hematological Cancers and Myelodyplastic Syndromes in HIV-infected Patients
A Multi-Center, Phase III, Randomized Trial of Reduced Intensity(RIC) Conditioning and Transplantation of Double Unrelated Umbilical Cord Blood (dUCB) versus HLA-Haploidentical Related Bone Marrow (Haplo) for Patients with Hematologic Malignancies
A Multi-Center Biologic Assignment Trial Comparing Reduced Intensity Allogeneic Hematopoietic Cell Tranplant to Hypomethylating Therapy or Best Supportive Care in Patients Aged 50-75 with Intermediate-2 and High Risk Myelodysplastic Syndrome
​1202​​Prospective Multi-Center Cohort for the Evaluation of Biomarkers Predicting Risk of Complications and Mortality Following Allogeneic HCT
​1203 PROGRESS I: A Multi-center Phase II Trial Randomizing Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls
​1204 ​Reduced-intensity Conditioning for Children and Adults with Hemophagocytic Syndromes or Selected Primary Immune Deficiencies
​1205​Easy-to-Read Informed Consent (ETRIC) for Hematopoietic Cell Transplantation Clinical Trials.
A Randomized, Multi-Center, Phase III Trial of Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease
Multicenter Phase II, Double-blind Placebo Controlled Trial of Maintenance Ixazomib after Allogeneic Hematopoietic Stem Cell Transplantation for High Risk Multiple Myeloma
​1304DETERMINATION; DFCI 10-106: A Randomized Phase III Study Comparing Conventional Dose Treatment Using a Combination of Lenalidomide, Bortezomib and Dexamethasone (RVD) to High-Dose Treatment with Peripheral Stem Cell Transplant in the Initial Management of Myeloma in Patients up to 65 Years of Age
A Phase II Multicenter Trial of Single Autologous Hematopoietic Cell Transplant Followed by Lenalidomide Maintenance for Multiple Myeloma with or without Vaccination with Dendritic Cell/Myeloma Fusions
​1501​A Randomized, Phase II, Multicenter, Open Label, Study Evaluating Sirolimus and Prednisone in Patients with Refined Minnesota Standard Risk, Ann Arbor 1/2 Confirmed Acute Graft-Versus-Host Disease
​1505​A Randomized Intervention Trial

Last Updated: 10/7/2021 2:45 PM