The CIBMTR Research Database contains hematopoietic cell transplantation (HCT) and cellular therapy information for recipients and their donors. CIBMTR collaborates with centers from around the world to collect clinical information from allogeneic and autologous transplants performed worldwide, including nearly all allogeneic transplants and approximately 80% of the autologous transplants performed in the U.S.

Information available for research purposes

The CIBMTR supports investigators in conducting HCT and cellular therapy observational studies. Information available for this research includes:

Baseline recipient data

• Diagnosis – disease sub-classification or histology, stage at transplant, cytogenetics, molecular markers, pre-HCT disease treatment
• Demographic – socioeconomic information, gender, age, race/ethnicity
• Transplant procedure – HLA typing, conditioning regimen, graft source, mobilization, T-cell depletion, and other graft manipulation
• Clinical – coexisting diseases, pre-HCT infection, HCT history

Baseline donor data

• Demographics
• HLA typing
• Infectious disease markers
• Pre-donation CBC and differential
• Pre-donation toxicities
• Filgrastim administration

Follow-up recipient data

Collected at 100 days, 6 months, and annually after HCT:

• Transplant outcomes:
  • survival
  • neutrophil and platelet engraftment
  • acute and chronic GVHD
  • relapse
• GVHD prophylaxis
• Immune reconstitution
• Chimerism
• Infection
• Organ function
• Subsequent HCT or DCI
• New malignancy
• Cause of death

Follow-up donor data

Collected at 2 days, 1 week, and weekly until donor reports full recovery, then at 1 month, 6 months, and annually after donation:

• Donor outcomes – post-donation CBC and differential, post-donation toxicities, adverse events
• Product analysis – cell counts, viability, volume

Investigators are welcome to view the data collection forms and the Data Management Manual for more information on the collection of recipient and donor data.

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Information available for request

To aid in clinical decision-making, protocol development, or other information-specific needs, CIBMTR offers access to descriptive statistics for populations of interest and/or a univariate analysis of overall survival. These data are available to investigators, physicians, corporations, and individuals worldwide upon request.

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