aGVHD Risk Index (GRI)

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Recipient Race and Ethnicity -- White non-Hispanic Black or African American non-Hispanic Asian non-Hispanic Native Hawaiian or other Pacific Islander non-Hispanic American Indian or Alaska Native non-Hispanic More than one race non-Hispanic Hispanic Missing

Karnofsky Performance Status at HCT -- KPS >= 90 (90 > KPS >= 80) (80 > KPS >= 70) (70 > KPS >= 60) KPS < 60 Missing

HCT Comorbidity Index -- 0 1 2 3 4 5 6+ Missing

Disease -- AML; Intermediate cytogenetics; CR1 AML; Favorable cytogenetics; CR1 AML; Favorable cytogenetics; CR2 AML; Favorable cytogenetics; CR3/PIF/relapse AML; Intermediate cytogenetics; CR2 AML; Intermediate cytogenetics; CR3/PIF/relapse AML; Poor cytogenetics; CR1 AML; Poor cytogenetics; CR2 AML; Poor cytogenetics; CR3/PIF/relapse AML; Cytogenetics unknown; CR1 AML; Cytogenetics unknown; CR2 AML; Cytogenetics unknown; CR3/PIF/relapse ALL; Poor cytogenetics; CR1 ALL; Poor cytogenetics; CR2 ALL; Poor cytogenetics; CR3/PIF/relapse ALL; Normal cytogenetics; CR1 ALL; Normal cytogenetics; CR2 ALL; Normal cytogenetics; CR3/PIF/relapse ALL; Cytogenetics unknown; CR1 ALL; Cytogenetics unknown; CR2 ALL; Cytogenetics unknown; CR3/PIF/relapse MDS; IPSS-R Very Low MDS; IPSS-R Low MDS; IPSS-R Intermediate MDS; IPSS-R High MDS; IPSS-R Very High MDS; IPSS-R unknown Non-Hodgkin Lymphoma; Chemosensitive Non-Hodgkin Lymphoma; Chemoresistant Hodgkin Lymphoma; Chemosensitive Hodgkin Lymphoma; Chemoresistant CML; Chronic phase/hematologic CR CML; Accelerated phase CML; Blast phase PLL; Chemosensitive (CR + PR + Nodular PR) PLL; Chemoresistant (Stable + Progressive) CLL; Chemosensitive (CR + PR + Nodular PR) CLL; Chemoresistant (Stable + Progressive) CMMoL; IPSS-R Very Low CMMoL; IPSS-R Low CMMoL; IPSS-R Intermediate CMMoL; IPSS-R High CMMoL; IPSS-R Very High CMMoL; IPSS-R unknown Other acute leukemia; CR1 Other acute leukemia; CR2 Other acute leukemia; Advanced/active/PIF/relapse Multiple Myeloma / Plasma cell disorder (PCD) MPN; DIPSS Low MPN; DIPSS Intermediate-1 MPN; DIPPS Intermediate-2 MPN; DIPSS High MPN; DIPSS unknown Severe aplastic anemia Inherited abnormalities erythrocyte function or differentiation

ATG/Campath Use -- No ATG or CAMPATH ATG alone CAMPATH alone

GVHD Prophylaxis -- Post-CY + other(s) TAC + MMF +- other(s) (except post-CY) TAC + MTX +- other(s) (except MMF, post-CY) TAC + other(s) (except MMF, MTX, post-CY) CSA + MMF +- other(s) (except post-CY) CSA + MTX +- other(s) (except MMF, post-CY) CSA + other(s) (except MMF, MTX, post-CY) Mmf +/- others (not CSA/Tacro/mtx/siro) MTX +/- others (not CSA/Tacro/MMF/siro) Siro +/- others (not CSA/Tacro/mmf/mtx) Mmf + siro +/- others (not CSA/Tacro/mtx)

Conditioning Regimen -- MAC-BU/CY MAC-BU/CY/Others MAC-BU/FLU MAC-BU/FLU/Others MAC-BU/Others (not cy or flu) MAC-CY/TBI MAC-CY/TBI/Others MAC-mel/others MAC-TBI+/-Others MAC-TBI+BU +/- Others MAC-TBI+BU/CY +/- Others MAC-TBI+BU/FLU +/- Others MAC-TBI+Thio-based MAC-Thio+others MAC-treo based NST-F/C +/- Others NST-F/C/T NST-F/T NST-Others RIC-BEAM/BEAM like RIC-BU +/- Others RIC-Flu/Mel +/- Others RIC-Others RIC-TBI +/- Others RIC-TBI+BU/FLU +/- Others RIC-TBI+FLU/CY +/- Others RIC-TBI+FLU/MEL +/- Others Missing

Cord Blood (Cord Blood vs. non-Cord Blood) -- Non-CB CB

Recipient CMV Serostatus (in CB) -- CB - recipient + CB - recipient -

Donor/Recipient CMV Serostatus (non-CB) -- +/+ +/- -/+ -/- Missing

Donor/Recipient ABO Match (non-CB) -- Matched Minor mismatch Major mismatch Bi-directional Missing

Donor/Recipient Sex Match (non-CB) -- M-M M-F F-M F-F Missing

Donor and Graft Type (non-CB) -- PB Well Matched Unrelated BM HLA Identical Sibling BM Other Related BM Well Matched Unrelated BM Partially Matched URD BM Mismatched URD BM URD (matching indeterminate) PB HLA Identical Sibling PB Other Related PB Partially Matched URD PB Mismatched URD PB URD (matching indeterminate)