Immunobiology Working Committee Studies
The Immunobiology Working Committee provides scientific oversight for studies related to histocompatibility and other genetic and immunologic issues related to hematopoietic cell transplantation (HCT).
Learn more about the studies conducted through the Immunobiology Working Committee using the links below.
Studies In Progress
| Number | Title | Status |
|---|
| R02-40s/R03-63s |
Choosing donors with favorable KIR B genotypes for unrelated hematopoietic cell transplantation (HCT) results in superior relapse protection and better relapse-free survival for patients with acute myeloid leukemia (AML). |
Ongoing
Abstract(s)
Publication(s)
|
| R03-70s |
Candidate gene study to examine the impact of chemokine and chemokine receptor gene polymorphisms on the incidence and severity of acute and chronic GVHD. |
Published
|
| R04-98s |
Detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated stem cell transplantation (HCT) and their relationship to graft/patient outcome. |
Published
|
| IB06-03 |
One antigen mismatch related donor vs. HLA-matched unrelated donor hematopoietic transplantation (HCT) in patients with acute leukemia: results in the era of molecular typing. |
Submitted
|
| IB06-06 |
Comparison of transplant outcomes using HLA -identical siblings, single antigen mismatched related donors, phenotypically matched related donors or HLA -A, -B, -C and -DRB1 matched unrelated donors for treatment of malignant disease in children. |
Submitted
|
| IB07-02 |
The effect of HLA mismatches at the amino acid level on hematopoietic stem cell transplantation (HCT). |
Submitted
|
| IB05-03s |
Genetic polymorphisms in the genes encoding human IL-7 Receptor-a: Prognostic significance in allogeneic stem cell transplantation (HCT). |
Manuscript Preparation
|
| IB06-02 |
Impact of mismatches in low expression HLA loci on the outcome of unrelated donor transplantation (HCT). |
Manuscript Preparation
|
| IB06-04 |
Effect of age on outcome in patients undergoing related HLA mismatched/haploidentical stem cell transplantation (HCT). |
Manuscript Preparation
Abstract(s)
|
| IB06-05 |
Use of high-resolution HLA data from the National Marrow Donor Program for the International Histocompatibility Working Group (IHWG) in hematopoietic cell transplantation (HCT). |
Manuscript Preparation
|
| IB06-09s |
Detection of HLA antibody to the mismatched antigen in single antigen HLA-mismatched unrelated donor transplantation (HCT): Is it associated with GVHD outcome? |
Manuscript Preparation
|
| IB07-01 |
Evaluation of HLA matching requirements for peripheral blood stem cells (PBSC) in unrelated hematopoietic stem cell transplantation (HCT). |
Manuscript Preparation
|
| IB07-06 |
Human leukocyte antigen: DP epitope study. |
Manuscript Preparation
|
| IB07-07 |
HLA -DR15 and hematopoietic stem cell transplantation (HCT) outcome. |
Manuscript Preparation
|
| IB07-09 |
To develop and test a prognostic index for survival in chronic myelogenous leukemia matched unrelated donor cohorts. |
Manuscript Preparation
|
| R03-65s |
Detection of H-Y antibodies in healthy female donors: Does H-Y presensitization predict male hematopoietic stem cell transplantation (HCT) outcome. |
Manuscript Preparation
|
| R04-74s |
Functional significance of Killer-IG-ligand genes in HLA-matched and mismatched unrelated hematopoietic cell transplantation (HCT). |
Manuscript Preparation
Publication(s)
|
| R04-75s |
Functional significance of cytokine gene polymorphisms in modulating risk of post-transplant complications. |
Manuscript Preparation
|
| R04-76s |
Identification of functional single nucleotide polymorphisms (SNPs) in unrelated hematopoietic cell transplantation (HCT). |
Manuscript Preparation
|
| IB05-02s |
Effect of single Class I mismatching on unrelated donor hematopoietic stem cell transplantation (HCT). |
Analysis
|
| IB07-04 |
Employing advanced bioinformatic methods for predicting peptide specificities of HLA molecules in the characterization of permissible mismatches in hematopoietic cell transplantation (HCT). |
Analysis
|
| IB07-05 |
Impact of donor-recipient ethnicity on risk of acute GVHD (GVHD) among HLA -A, B, C, DRB1, DQB1, DPB1 matched unrelated donor transplants. |
Analysis
Abstract(s)
|
| IB07-08s |
Single nucleotide polymorphisms in the P53 Pathway (P53, MDM2, ATM AND P21/WAF1) and transplant outcome after unrelated haematopoietic stem cell transplantation (HCT). |
Analysis
|
Planned Studies
Recently Published Studies
