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Patient-Centered Research and Implementation Science

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Implementation science is a systematic way to approach the broader adoption of evidence-based practices. Its goal is to understand and address the gap between research and practice, ensuring that research findings are effectively translated into practice and policy to improve health outcomes and service. CIBMTR’s Implementation Science Team systematically closes the gap between what we know and what we do by:

  • Disseminating Research. Sharing research findings with specific audiences to improve awareness of the results.
  • Understanding Current Practice. Conducting studies and analyses to understand the current state of evidence-based practices and potential barriers to adoption.
  • Supporting Implementation. Designing and deploying implementation strategies to enhance the uptake of evidence-based practices.

Examples include:

  • Inequities in access to and utilization of cellular therapies resulting from social determinants of health-related barriers and genetic risk factors
  • Treatment decision-making support, including for clinical practice and quality / value of care
  • Health economics and outcomes research, including healthcare utilization
  • Development and implementation of health equity toolkit
  • Prospective understanding of factors that influence the successful integration of trial interventions into clinical practice
  • Interventions to improve adoption of best practices for testing and management of donor-specific antibodies

Studies

Studies in Progress

Title Status
Characteristics of high- and low-performing allogeneic transplant centers Protocol Development
​Patient perspectives on palliative care1 Protocol Development
Access to transplant for patients with acute myelogenous leukemia in the state of Virginia2 Protocol Development
Health care utilization and costs associated with patients with sickle cell disease enrolled in Medicaid Protocol Development
Linking the Center for International Blood and Marrow Transplant Research (CIBMTR) Registry to the California Cancer Registry, Vital Statistics, and Hospital Patient Discharge database to study adverse effects and survival following hematopoietic cell transplantation3 Protocol Development
INSPIRE: A multicenter randomized controlled trial integrating health informatics in a scalable stepped care self-management program for survivors after hematopoietic cell transplantation4 Accrual
Patient perceptions of important clinical trials outcomes5 Accrual
Medicaid coverage for hematopoietic cell transplantation in sickle cell disease patients: A policy analysis Accrual
Hematopoietic cell transplantation for older adults practice survey6 Data Collection​
Hematopoietic cell transplantation predictions for the Year 20237 Data Analysis​

Research conducted in partnership with: 1Massachusetts General Hospital, 2University of Virginia, 3California Cancer Registry, 4Fred Hutchinson Cancer Research Center and CIBMTR RCI BMT, 5Fred Hutchinson Cancer Research Center, 6Moffitt Cancer Center, and 7University of Florida.

Publications

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