Information for Researchers
Introduction
The Center for International Blood and Marrow Transplant Research (CIBMTR) is comprised of clinical and basic scientists in more than 459 institutions in 52 countries who voluntarily submit data on their consecutive allogeneic and syngeneic or autologous hematopoietic stem cell transplant (HSCT) recipients to a Statistical Center at the Medical College of Wisconsin.
Based on data collected in the Centers for Disease Control Hospital Surveys and the U.S. Government Accounting Office and worldwide surveys of transplant activity, approximately 40% of allogeneic transplants worldwide and about 50% of autotransplants done in North and South America are registered with the CIBMTR.
Objectives
Objectives of the Center for International Blood and Marrow Transplant Research (CIBMTR) are to develop and maintain a comprehensive database of clinical information on recipients of blood and bone marrow transplants, to conduct clinical studies addressing important issues in transplantation and cancer treatment, and to serve as an information resource for issues related to blood and bone marrow transplantation.
Scope of Studies
The Center for International Blood and Marrow Transplant Research (CIBMTR) addresses questions regarding short- and long-term outcomes in defined groups of patients, relevant prognostic factors, efficacy of different transplant approaches, and immune-mediated anti-tumor effects. Recent collaborations with large chemotherapy cooperative groups allow us to compare chemotherapy with transplants in situations where randomized clinical trials are difficult or impossible to conduct.
How Data is Collected
The Center for International Blood and Marrow Transplant Research (CIBMTR) collects data at two levels:
- Registration data include disease type, age, sex, pretransplant disease stage and chemotherapy-responsiveness, date of diagnosis, graft type (bone marrow- and/or blood-derived stem cells), high-dose conditioning regimen, posttransplant disease progression and survival, development of a new malignancy and cause of death. Requests for data on progression or death for registered patients are at six-month intervals. All CIBMTR teams contribute registration data.
- Research data is collected on subsets of registered patients and includes comprehensive pre- and posttransplant clinical information.
How to Use CIBMTR Data
If you are a transplant researcher making treatment decisions or planning clinical studies, contact Tanya Pedersen at info-request@mcw.edu for specific BMT statistical information.
If you are interested in proposing a study to be conducted by one of the CIBMTR Working Committees, using CIBMTR data, please review the Working Committee study guidelines.
If you are in industry and would like a simple analysis from the CIBMTR database, our Corporate Membership Program can help.
If you are looking to conduct an industry study, such as comparing transplant with non-transplant treatment or using historical controls, contact Sherry Fisher, Associate Director of Development, at slfisher@mcw.edu for more information or to determine a budget on an individual study basis.